Finnish Centre for Alternative Methods (FICAM)
FICAM develops and validates human-cell-based tissue/organ models, shares information on alternative methods, educates experts, and acts as the Finnish reference laboratory for EURL-ECVAM (European Union Reference Laboratory for Alternatives to Animal Testing). The basis of FICAM’s activity lays on EU directive 2010/63, according to which the use of experimental animals should be reduced and replaced with non-animal experimentation in research and education as soon as it is scientifically possible.
The area of the multidisciplinary expertise in FICAM covers the development of human- cell-based methods to be used in regulatory toxicology, mechanistic toxicology, cell biology, tissue technology, selected disease models, and cell imaging.
FICAM tissue/organ models are based on cells differentiated from human (adult) stem cells or human primary cells. The models combine several cell types of a tissue with supporting material to mimic the normal functions of human tissues. The Adverse Outcome Pathway (AOP) is a leading principle in the strategy of model and assay development.