Finnish Centre for Alternative Methods (FICAM)
FICAM develops and validates human-cell-based tissue/organ models, shares information on alternative methods, educates experts, and acts as the Finnish reference laboratory for EURL-ECVAM (European Union Reference laboratory for Alternatives to Animal Testing). FICAM’s foundation and activity is based on the EU Directive of 2010/63, according to which the use of experimental animals should be reduced and replaced with non-animal experimentation, in research and education, as soon as scientifically possible.
The multidisciplinary expertise in FICAM covers the development of human- cell-based methods to be used in regulatory toxicology, mechanistic toxicology, cell biology, tissue technology, selected disease models, and cell imaging.
FICAM tissue/organ models are based on cells differentiated from human (adult) stem cells or primary human cells. The models combine several tissue cell types, with supporting material to mimic the normal functions of human tissue. The Adverse Outcome Pathway (AOP) is a leading principle in the strategy of model and assay development.