Swedish Toxicology Sciences Research Center
There is a great need to produce new tools and methods for assessing the safety of chemicals. These needs stem from both governmental agencies and innovative activities in the development of pharmaceuticals, cosmetics and other consumer chemicals.
Swetox will be among the first research centers that, from their launch, will base their work on the principles of the 3Ms (Mechanisms, Models and Markers) and 3Rs (Reduce, Replace, Refine). This necessitates a focus on safety assessment, which is targeted through improving the understanding of toxicological mechanisms, the development of new biomarkers of toxicity, and the development of new experimental models. All of these developments are focused on mode of action-based safety assessments in humans.
Implicit in these 3M aims is the adherence to the principles of the 3Rs; these principles direct efforts toward reducing the number of animals used in testing, the development of more refined animal-based test methods, and the replacement of animal testing with suitable and validated alternatives. Thus, Swetox will play a key role in the effort to develop and implement new methods within the 3Rs in general.