A Refined Approach to Producing Polyclonal Antibodies in Chickens – Completely Replacing All Invasive Elements by Combining Immunizations with Routine Aerosol-based Vaccinations (finished project)

Contact: Otto Kalliokoski

The aim is to exploit routine vaccination of chickens, administered in aerosol form, to raise antibodies against a model immunogen (a protein) coupled to the surface of the vaccine’s virus particles. Combined with isolation/purification of antibodies from egg yolk, this method will not only reduce the number of animals needed in the production of polyclonal antibodies, but also completely eliminate the need of invasive procedures associated with conventional antibody production, thus constituting an immense refinement of methodology.

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